Abstract: Renshen Pingfei San, formulated by Li Dongyuan, a physician of the Earth-Tonifying School during the Jin and Yuan Dynasties, is a classic prescription for invigorating qi and clearing the lungs, and was originally used to treat lung atrophy due to the punishment of the lung by heart fire. Later physicians have expanded its applications. By sorting out the origins and development of this prescription, comparing its formulation and compatibility characteristics with Xiebai San, and the evolved formulations and expanded application scope in later generations, support is provided for the clinical application of Renshen Pingfei San.