基于UPLC-Q/TOF-MS结合多元统计学方法分析不同来源乳香的化学成分

Analysis of the Chemical Compositions of Olibanum of Different Origins Based on UPLC-Q/TOF-MS Combined with Multivariate Statistics Methods

    摘要
  • 摘要:
    目的 分析不同来源乳香的差异性化学成分，为乳香的产地判别和质量标准制定提供有效参考。
    方法 采用超高效液相色谱-四极杆飞行时间串联质谱(UPLC-Q/TOF-MS)对乳香的化学成分进行分析，并结合多元统计学方法对不同来源乳香药材及炮制品进行分析，筛选不同来源乳香的差异性化合物。
    结果 采用正负离子扫描模式，共鉴定出乳香含有108个化合物；化合物以萜类成分为主，其中三萜类成分含量最高。通过多元统计学方法分析发现，不同来源乳香的化学成分差异明显，共得到34种差异性化合物，并且寻找到不同来源乳香的特征性成分。
    结论 差异性化学成分可作为乳香来源鉴别以及后续乳香药效物质基础研究的依据。

     

    Abstract:
    OBJECTIVE To analyze the differential chemical composition of Olibanum of different origins and to provide some references for the identification of Olibanum origin and the quality standards.
    METHODS The chemical compositions of Olibanum were analyzed by UPLC-Q/TOF-MS. Multivariate statistical methods were used to analyze Olibanum and processed products to screen the differential compounds in Olibanum of different origins.
    RESULTS Using positive and negative ion scanning modes, a total of 108 compounds were identified in Olibanum. The compounds were mainly terpenes, among which triterpenes were the highest. And through multivariate statistical analysis, it was found that there were significant differences in the chemical compositions of Olibanum of different regions, with a total of 34 differential compounds; furthermore, specific compounds unique to Olibanum from other sources were identified.
    CONCLUSION Different regions of Olibanum could be distinguished based on their differential chemical compositions. This study could serve as a basis for identifying different origins of Olibanum, and also provide experimental data for subsequent research on the pharmacological substance basis of Olibanum.

     

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