OBJECTIVE To explore the clinical efficacy of Suyin Jiedu Prescription in the treatment of Stage 3-5 non-dialysis chronic kidney disease of kidney deficiency and turbid toxin type and its effect on serum Klotho and inflammation levels.

METHODS A total of 102 patients with Stage 3-5 non-dialysis chronic kidney disease of kidney deficiency and turbid toxin type who met the inclusion criteria were randomly divided into a treatment group and a control group, 51 cases in each group; a total of 84 cases were completed, including 44 cases in the control group and 40 cases in the treatment group. The control group was given conventional Western medicine basic treatment, and the treatment group was given Suyin Jiedu Prescription on the basis of the control group treatment. The treatment course of both groups was 16 weeks. The levels of renal function indexes hemoglobin (Hb), serum albumin (Alb), urea nitrogen (BUN), serum creatinine (Scr), estimated glomerular filtration rate (eGFR), 24 h urine protein (UTP) and TCM syndrome scores were observed in the two groups before and after treatment. The levels of serum Klotho, tumor necrosis factor α (TNF-α) and interleukin 18 (IL-18) were detected by ELISA. The clinical efficacy between the two groups after treatment was compared.

RESULTS After treatment, BUN and Scr levels of the two groups of patients were significantly decreased (P < 0.05), eGFR was significantly increased (P < 0.05, P < 0.01), the treatment group was better than the control group (P < 0.05); the TCM syndrome scores of the two groups were significantly decreased (P < 0.05, P < 0.01), and the treatment group was better than the control group (P < 0.05, P < 0.01); the serum Klotho level in the treatment group was significantly increased (P < 0.05), the IL-18 level was significantly decreased (P < 0.01), and the serum Klotho, TNF-α, and IL-18 levels in the treatment group were better than those in the control group (P < 0.05, P < 0.01). The total clinical effective rate in the treatment group was higher than that in the control group (P < 0.01).

CONCLUSION Suyin Jiedu Prescription can effectively improve renal function and relieve clinical symptoms in patients with Stage 3-5 non-dialysis chronic kidney disease of kidney deficiency and turbid toxin type, which may be related to increasing Klotho level and reducing inflammation in the body.