Abstract: "When warm evil is received, it first attacks the lungs and then spread to the pericardium reversely" is the general rule of warm diseases. Doctors of different dynasties have different views on the phrase "reverse spread to the pericardium", especially the word "reverse". Professor Tong Xiaolin proposed that the heart governs the mind, the pericardium and the heart are connected in qi, and when the heart is affected by evil, the pericardium instead suffers from the evil. The "reverse spread to the pericardium" proposed by Ye Tianshi is actually the spread of warm evil to the brain. Taking meningococcal meningitis as the basic disease, it can be matched one by one with the typical stages of the transmission of Wei-Qi-Ying-Xue. Combined with the theory of Dingjiao, it is believed that the function of "the heart governing the mind" focuses more on the brain in the modern anatomical sense. Combining traditional Chinese medicine's ideas on diagnosis and treatment of warm diseases with modern medicine, revealing the essence of the disease, grasping the core of the pathogenesis, analyzing the word "reverse" from a new perspective, and exploring its true meaning, is of great significance for clarifying its connotation, exploring the development laws of warm diseases, and guiding the diagnosis and treatment of warm diseases.