Abstract: This paper summarizes Professor Zhou Fuyi's experience in treating degenerative knee osteoarthritis from the perspective of "blood stasis leading to decline". He believes that degenerative knee osteoarthritis syndrome is characterized by deficiency of the root and excess of the superficial, decline of the root and paralysis of the superficial, with deficiency of the liver, spleen and kidney as the root. The deficiency of healthy qi weakens the ability to resist the evil, with the invasion of wind, cold, and dampness, the lingering of the evil and the obstruction of stasis, long-term illness entering the collaterals accompanied by dampness and phlegm, blood stasis and blood deficiency being mutually causal. He treats degenerative knee osteoarthritis from the perspective of stasis, with the removal of stasis and the promotion of new blood as the main treatment method, and both nourishing blood and activating blood circulation are given equal importance. In clinical application, it is divided into the early stage of stasis, the stasis stage and the late stage of stasis, with removing evil and unblocking collaterals, promoting qi and activating blood circulation, and nourishing liver and kidney as the treatment principles and methods, respectively. Activating blood circulation and removing stasis are carried out throughout the treatment of the disease, achieving good clinical efficacy.