Abstract: Professor Nan Zheng, a master of traditional Chinese medicine, put forward a new TCM disease name of "diabetes renal failure" for diabetic nephropathy, and established the pathogenesis theory of "toxin damaging kidney collaterals" based on the theory of "lung wei-moyuan-kidney" theory. He believes that lung-kidney correlation and lung wei damage are the initiating factors of diabetes renal failure; the pathogenic toxin retained in moyuan is the pivot of diabetes renal failure, and toxin damaging kidney collaterals is the root cause of diabetes renal failure. He also established the "Jiedu Tongluo Daoxie Method" to treat diabetes renal failure, the core treatment principle of which is to adjust the paste, reach moyuan, detoxify and dredge the collaterals, and expel the evil. At the same time, it is combined with the external use of Chinese medicine enema prescription, treating both internally and externally, attacking and supplementing simultaneously, with significant clinical efficacy.