OBJECTIVE To explore the clinical efficacy of Chaihu Jia Longgu Muli Decoction Derivative in the treatment of non-valvular paroxysmal atrial fibrillation based on the pathogenesis theory of "mutual fanning of liver wind and heart fire".

METHODS A total of 80 patients with non-valvular paroxysmal atrial fibrillation admitted to Hainan Provincial Traditional Chinese Medicine Hospital from January 2021 to July 2022 were prospectively selected as the research subjects and randomly divided into an observation group and a control group with 40 cases in each group. The control group was given conventional treatment such as western medicine anticoagulation and ventricular rate control. The observation group was given Chaihu Jia Longgu Muli Decoction Derivative on the basis of the control group. The treatment course of both groups was 30 d. The two groups were compared in terms of TCM syndrome scores, atrial fibrillation episodes (number of episodes, duration), clinical efficacy, changes in electrocardiogram parameters (P wave duration, P wave dispersion), heart rate variability indexes, left ventricular function indexes and the occurrence of adverse reactions.

RESULTS After treatment, the TCM syndrome scores of the two groups of patients were significantly reduced (P < 0.05, P < 0.01), and the observation group was better than the control group (P < 0.05, P < 0.01); the number and duration of atrial fibrillation in the two groups were significantly decreased (P < 0.05, P < 0.01), and the observation group was superior to the control group (P < 0.05, P < 0.01); the clinical efficacy of the observation group was better than that of the control group (P < 0.05); the heart rate variability indexes, electrocardiogram parameters and left ventricular function indexes were significantly improved (P < 0.05), and the observation group was superior to the control group (P < 0.05); there was no significant difference in the occurrence of adverse reactions between the two groups (P > 0.05).

CONCLUSION Based on the pathogenesis theory of "mutual fanning of liver wind and heart fire", the application of Chaihu Jia Longgu Muli Decoction Derivative for the treatment of non-valvular paroxysmal atrial fibrillation can improve clinical symptoms, reduce atrial fibrillation, enhance cardiac function, and has good clinical efficacy.