Abstract: There is a dynamic and progressive relationship in acute pancreatitis (AP), following the principle of Wei-Qi-Ying-Xue transmission in traditional Chinese medicine (TCM). The metabolic disorders prevalent in AP can be attributed to the "turbid toxin" category in TCM, which runs throughout the disease as causative factors and pathologic products. The abnormal metabolism of subtle substances is the initiating factor of Wei-Qi-Ying-Xue transmission. Disorders of energy metabolism lay the pathologic basis of turbid evil and stagnant heat in the Qi stage of AP. Changes in the metabolic environment further exacerbate the inflammatory response resulting in the exuberance of pathogenic heat and the accumulation of blood stasis and toxins, promoting AP from the Qi division into the Ying-Xue stage. Therefore, we propose that "holding the Qi-fen juncture" and restoring metabolic homeostasis may be the keys to early truncation of AP disease progression. This paper explores the pathogenesis connotation of Wei-Qi-Ying-Xue transmission in AP from a metabolic perspective combined with the turbid toxin theory, which not only enriches the scientific connotation of Wei-Qi-Ying-Xue syndrome differentiation but also provides new ideas for the prevention and treatment of severe AP with TCM.