Abstract: Through studying Chen Yiren's works, this paper summarizes Chen Yiren's academic thought of diligently seeking and learning, thinking about the purpose of the classics, exploring the essence of the theory, and studying the prescriptions and techniques, and expounds Chen Yiren's experience of "learning, studying, distinguishing, and applying" Treatise on Cold Damage. Professor Chen Yiren advocates the combined theory of external and internal injuries, the "six meridians regulating all diseases" theory, and "bad diseases being difficult and complicated diseases" theory. His thought on studying is reflected in the following four aspects: learn, diligently seeking and learning, and teaching people the law, citing evidence from various schools, distinguishing syndromes and seeking causes, connecting with clinical practice, and summarizing the three methods of selecting prescriptions; research, thinking about the purpose of the classics and explaining the key points, summarizing the five major characteristics of Treatise on Cold Damage of "differentiation, change, strictness, flexibility, and simplicity", explaining that Yangming disease has no distinction between meridians and viscera, and emphasizing the combination of pulse and syndromes; distinguish, exploring the principles, distinguishing doubts and resolving confusion, revealing the rules of diagnosis and treatment of bad diseases, showing people the "living" method, discussing the prescriptions and syndromes of Jueyin disease, and focusing on applying the ancient to the present; apply, studying the prescriptions and techniques carefully and differentiating flexibly, explaining that the six meridians regulates hundreds of diseases, distinguishing complex and difficult diseases and syndromes, clarifying the complications and suspected syndromes, using the differentiation method flexibly, and opening up ideas for the use of classic prescriptions. In addition, Chen Yiren emphasizes the important position of the Treatise on Cold Damage course in TCM education and talent training, which should be strengthened during education and teaching as well as curriculum construction, making great contributions to the inheritance and development of Treatise on Cold Damage.