Abstract: This paper explores the possibility of improving syndrome differentiation system of weifen, qifen, yingfen and xuefen. Clinical manifestations of xuefen syndrome in warm diseases are diverse with complex pathogenesis. Based on the previous research of the research group and the theories of essence and marrow, combined with characteristics of bleeding, organ failure, abnormal consciousness, and spasms in the extreme and late stages of warm diseases, it is suggested that the traditional xuefen syndrome should be further subdivided into xuefen syndrome mainly characterized by disorders in blood generation, circulation, and function, jingfen syndrome mainly characterized by organ failure, and suifen syndrome mainly characterized by symptoms of consciousness and nervous system abnormalities. Adopting six stage differentiation and treatment of weifen, qifen, yingfen, xuefen, jingfen and suifen not only expands the progressive pattern of warm disease pathogenesis, deepens the understanding of the pathogenesis essence of each stage in warm diseases, especially the extreme and late stages, promotes the precision of treatment guides and prescriptions, but also helps us understand the common transformation and evolution laws of external and internal diseases, and thus improves the diagnosis and treatment effectiveness.