Abstract: Guided by the cancer toxin theory of TCM master Professor Zhou Zhongying, and absorbing the thoughts of academician Tong Xiaolin's theory of state-target, the pathogenesis of multiple myeloma is summarized as deficiency of healthy qi, bone erosion and marrow damage, cancer toxin accumulation, phlegm and stasis mingling, the combat between healthy qi and evil qi, and dynamic evolution; a full-cycle anti-cancer and detoxification prevention and treatment strategy for multiple myeloma is proposed that incorporates the ideas of nourishing deficiency and strengthening healthy qi, preventing cancer and detoxification, resolving phlegm and removing stasis throughout the entire treatment process. The scientific connotation of the pathogenesis theory of "healthy qi deficiency and cancer toxin" in multiple myeloma is explained from multiple aspects such as protein overload and tumor microenvironment, and a prescription-drug medicine system with Xuanbi Xiaoliu Formula as the core is constructed, which provides new ideas and scientific basis for the clinical diagnosis and treatment plan and full-cycle prevention and control model of multiple myeloma combining Chinese and Western medicine.