Abstract: Animal models of TCM syndromes are the important carriers of revealing the basic theory of traditional Chinese medicine(TCM) and promoting the clinical development of TCM, and are indispensable tools to promote the modernization and internationalization of TCM. At present, the establishment methods of TCM syndrome animal model are varied and the evaluation criteria are different. Based on the main physiological functions of the five viscera, this paper summarized and analyzed the construction and evaluation methods of the most commonly used animal models of TCM syndromes in recent years, represented by the common clinical heart-qi deficiency syndrome, liver stagnation syndrome, spleen-qi deficiency syndrome, lung-qi deficiency syndrome and kidney-yang deficiency syndrome, in order to provide reference for establishing a more scientific and objective animal model construction method and evaluation system of TCM syndromes.