Abstract: Based on the research on the inheritance of clinical experience of traditional Chinese medicine (TCM) master Zhou Zhongying in the diagnosis and treatment of major chronic diseases, a decision support system for learning experience of Zhou Zhongying in diagnosing and treating major chronic diseases was constructed based on intelligent technology. First, the outpatient paper medical records kept by Professor Zhou Zhongying since the 1980s were digitized. Then, data mining was performed on the electronic database to form a structured database and knowledge element module network. Finally, the mined results were used to interview famous doctors. The promotion and application of this system in clinical practice has realized a new method of original inheritance and learning of the experience of Zhou Zhongying in diagnosing and treating major chronic diseases. It has greatly improved the diagnosis and treatment ideas of middle-aged and young Chinese medicine practitioners in dealing with personalized, complex and changeable major chronic diseases, breaking through the traditional one-to-one teaching model of "master-apprentice", and forming a new model of large-scale TCM inheritance education.