Abstract: Based on the physiological and pathological characteristics of "spleen is often insufficient" in Children, Professor Jiang Yuren put forward the academic view of "the health of the spleen is not replenished but regulated", and took "spleen regulation method" as the first choice for the treatment of spleen-stomach diseases such as anorexia, diarrhea, infantile malnutrition, iron deficiency anemia. By systematically analyzing the academic connotation, clinical practice, inheritance and development of Professor Jiang Yuren's "spleen regulation method" and combining with the current research progress, this article interprets the internal molecular mechanism of "spleen regulation method" to provide scientific basis for further promoting the clinical application and modern research of Professor Jiang Yuren's "spleen regulation method".