Abstract: Professor Qiu Maoliang, in his clinical practice and experience summary of acupuncture-moxibustion in the treatment of febrile diseases, proposes four acupuncture-moxibustion antipyretic methods, namely, releasing the exterior and reducing fever, clearing the interior and purging the heat, nourishing the yin and purging the heat, and assisting the yang and reducing fever, which respectively correspond to the exterior heat syndrome, interior heat syndrome, yin deficiency fever syndrome, and yang deficiency fever syndrome. The academic connotation of Professor Qiu Maoliang's acupuncture-moxibustion for fever can be summarized as examining the syndrome and seeking the cause, and classifying fever; coordinating the four methods of acupuncture-moxibustion and operation techniques, which reflect Professor Qiu Maoliang's academic characteristics, such as the convergence of Chinese and Western medicine, mutual learning of acupuncture-moxibustion and medicine, and the connection of effect mechanism and theory. Professor Qiu Maoliang's academic thought of acupuncture-moxibustion antipyretic method not only helps to provide basis for further application of acupuncture-moxibustion in contemporary clinical practice, but also enriches the modern biological connotation of acupuncture-moxibustion medicine.