Abstract: Through the study of the academic thought and clinical experience of TCM master, Professor Gan Zuwang, this paper summarizes and generalizes the formation background and theoretical connotation of Gan's academic thoughts on TCM otolaryngology, including the "mediator" theory, "five diagnosis and ten principles" theory, "imitation of the inner classic" theory, the creation of two new diseases, "excessive nasal discharge" and "laryngeal cough", the "spleen and stomach theory" of otolaryngology, and the first proposal of the "ten essentials of syndrome differentiation" and "nine methods of phlegm treatment" for otorhinolaryngological oral mucosa disease. The paper expounds the academic achievements and outstanding contributions of Professor Gan Zuwang in the field of TCM otolaryngology from the perspectives of holistic concept, syndrome differentiation and treatment, local syndrome differentiation of otolaryngology and other aspects of TCM otolaryngology diagnosis and treatment ideas and technical innovations, providing reference and inspiration for better inheritance of the academic experience of famous veteran TCM practitioners and the promotion of TCM otolaryngology development.