Abstract: To explore the connotation of the holistic view of "formula-disease-person" diagnosis and treatment model of Professor Huang Huang from the aspects of construction process, thinking dimension, clinical practice, etc. It's believed that "formula-disease-person" diagnosis and treatment model is based on the holistic view of "unity of form and spirit", and contains a wealth of constitution epistemology based on the holism of "form-qi-spirit", which has the characteristics of three-dimensional, scene character and embodiment. From the perspective of therapeutics, two key points are derived, namely "correspondence between formula and person" and "correspondence between formula and disease", which embodies the systematic and holistic thinking of "constitution differentiation, disease differentiation, syndrome differentiation, pathogenesis differentiation", emphasizes the unity of formula-person, formula-disease, formula-syndrome and formula-pathogenesis, and is the embodiment of the idea of combining disease and syndrome. The "formula-disease-person" diagnosis and treatment model combines the formula-syndrome view of "diagnosis-identification" and the treatment view of constitution differentiation-disease differentiation and incorporates a holistic view throughout the entire process of disease diagnosis and treatment, which has guiding significance for the treatment of chronic diseases and difficult diseases.