Abstract: This paper introduces Professor Huang Huang's clinical experience in treating depression with modified classical prescriptions of Zhongjing. Professor Huang Huang inherited and summarized Zhongjing's academic thoughts on treating emotional diseases, and formulated Jieyu Chufan Recipe by combining Banxia Houpu Decoction with Zhizi Houpu Decoction. He believes that depression is characterized by qi stagnation and phlegm obstruction, as well as internal disturbance of stagnation fire, and formulated a treatment method of clearing heat and eliminating restlessness, relieving depression and resolving phlegm. Professor Huang Huang uses Jieyu Chufan Recipe as the basic prescription, and combines relevant classical prescriptions with modifications to treat depression according to different constitutions and syndromes of patients, achieving satisfactory clinical results.