Abstract:
OBJECTIVE To evaluate the efficacy and safety of Huoxue Xiaoyi Granule in inhibiting the recurrence of endometriosis (EMs) after conservative operation, and to provide evidence for Chinese medicine in inhibiting the recurrence of EMs.
METHODS A total of 72 patients with qi-stagnation and blood-stasis after EMs operation were selected as the study objects and randomly divided into the Chinese medicine group and the Western medicine group, 36 cases in each group. The Chinese medicine group was treated with Huoxue Xiaoyi Granule, and the Western medicine group was treated with GnRH-α. The postoperative recurrence rate, TCM syndrome score, carbohydrate antigen 125 (CA125), dysmenorrhea score, pelvic pain score, pregnancy rate, serum sex hormones estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and safety indexes of the two groups were observed.
RESULTS At 9 months and 12 months after surgery, the total TCM syndrome scores of the two groups of patients were significantly reduced (P<0.05), and the Chinese medicine group was better than the Western medicine group (P<0.05); 12 months later, the TCM total clinical curative rate in the Chinese medicine group was better than that in the Western medicine group; after surgery, the serum CA125 levels, dysmenorrhea scores and pelvic pain severity of the two groups of patients were significantly reduced (P<0.05, P<0.01); during treatment, the total incidence of adverse reactions in the Chinese medicine group was lower than that in the Western medicine group (P<0.01); the recurrence rate of the Chinese medicine group was slightly lower than that of the Western medicine group, but there was no statistical difference (P>0.05).
CONCLUSION Huoxue Xiaoyi Granule can significantly improve TCM syndromes in patients with qi-stagnation and blood-stasis after EMs surgery. It is safe and has equivalent efficacy to GnRH-α in preventing postoperative recurrence of EMs, and worthy of clinical promotion and application.