陈雅茜, 李卓远, 陶琳, 陈娜娜, 柯益鑫, 沈雯, 谢薇, 张雯, 李俊松. 基于基准关联度与信息熵权法优选桂枝配方颗粒中挥发性成分的β-环糊精包合工艺[J]. 南京中医药大学学报, 2024, 40(6): 582-588. DOI: 10.14148/j.issn.1672-0482.2024.0582
引用本文: 陈雅茜, 李卓远, 陶琳, 陈娜娜, 柯益鑫, 沈雯, 谢薇, 张雯, 李俊松. 基于基准关联度与信息熵权法优选桂枝配方颗粒中挥发性成分的β-环糊精包合工艺[J]. 南京中医药大学学报, 2024, 40(6): 582-588. DOI: 10.14148/j.issn.1672-0482.2024.0582
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CHEN Yaxi, LI Zhuoyuan, TAO Lin, CHEN Nana, KE Yixin, SHEN Wen, XIE Wei, ZHANG Wen, LI Junsong. Optimization of β-cyclodextrin Inclusion Process of Cinnamomi Ramulus Formula Granules Volatile Constituents Based on Standard Relation and Information Entropy Method[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(6): 582-588. DOI: 10.14148/j.issn.1672-0482.2024.0582
Citation: CHEN Yaxi, LI Zhuoyuan, TAO Lin, CHEN Nana, KE Yixin, SHEN Wen, XIE Wei, ZHANG Wen, LI Junsong. Optimization of β-cyclodextrin Inclusion Process of Cinnamomi Ramulus Formula Granules Volatile Constituents Based on Standard Relation and Information Entropy Method[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(6): 582-588. DOI: 10.14148/j.issn.1672-0482.2024.0582
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基于基准关联度与信息熵权法优选桂枝配方颗粒中挥发性成分的β-环糊精包合工艺

Optimization of β-cyclodextrin Inclusion Process of Cinnamomi Ramulus Formula Granules Volatile Constituents Based on Standard Relation and Information Entropy Method

    摘要
  • 摘要:
      目的   结合基准关联度与信息熵权法，采用正交试验对β-环糊精(β-Cyclodextrin，β-CD)与桂枝配方颗粒中挥发性成分的包合工艺进行优化。
      方法   在单因素考察的基础上，选择β-CD与桂枝芳香水的投料比、包合温度、包合时间为主要影响因素，以包合物中桂皮醛的包合率、载药量及基准关联度为评价指标，采用信息熵权法计算各评价指标的权重系数，进行综合评价和优化正交试验包合工艺。通过薄层色谱法、紫外可见吸收光谱、傅里叶红外光谱、X射线衍射等方法对包合物进行表征。
      结果   优选的最佳包合工艺为β-CD与芳香水的投料比3 ∶ 100(g·mL-1)，包合温度50 ℃，包合时间1 h。经验证，桂皮醛包合率为80.48%，载药量为8.63%，基准关联度为0.91。薄层、紫外、红外等表征实验表明芳香水中挥发性成分成功进入β-CD空腔，包合物制备成功。
      结论   优选的包合工艺稳定可行，可为桂枝配方颗粒的制剂工艺研究提供参考。

     

    Abstract:
      OBJECTIVE   To optimize β-cyclodextrin (β-CD) inclusion process of Cinnamomi Ramulus Formula Granules volatile constituents by orthogonal test, based on standard relation and information entropy method.
      METHODS   On the basis of single factor experiments, the ratio of β-CD to aromatic aqueous solution, the inclusion temperature, and the inclusion time were selected as the investigating factors; the inclusion rate, drug loading, and standard relation of cinnamic aldehyde in inclusion complex were used as the evaluation index. The information entropy method was used to determine the weight coefficient of each index, then the comprehensive score was calculated, the inclusion process conditions were optimized by orthogonal experiment. The inclusion complex was characterized by thin layer chromatography, ultraviolet absorption spectroscopy, Fourier infrared spectroscopy, and X-ray diffraction.
      RESULTS   The best inclusion process was that the ratio of β-CD to aromatic aqueous solution was 3∶100 (g·mL-1), the inclusion temperature was 50 ℃, and the inclusion time was 1 h. The average inclusion rate of the obtained inclusion compound was 80.84%, the drug loading was 8.63%, and the standard relation was 0.91. The results of thin-layer chromatography, ultraviolet, infrared spectroscopy and other characterization experiments showed that the volatile components in the aromatic aqueous solution successfully entered the β-CD cavity, and the inclusion complex was successfully prepared.
      CONCLUSION   The optimum inclusion process is stable and feasible, which can provide references for the preparation process of Cinnamomi Ramulus Formula Granules.

     

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