Abstract: The five movements and six qi theory (hereinafter referred to as “movement qi theory”) runs through Liu Wansu’s medical theoretical system, which is mainly reflected in its influence on the theory of pathogenesis, the creation of fiery heat theory, and the influence of Liu Wansu’s clinical diagnosis and treatment thoughts. The influence of movement qi theory on Liu Wansu’s pathogenesis theory includes three aspects: six qi alternation on pathogenesis, five movement hyperactivities on pathogenesis, and the root and branch of movement qi on pathogenesis. Liu’s understanding of the pathogenesis of six qi and the philosophical thought of “water is good and fire is evil” mainly influenced the creation of Liu Wansu’s “fire theory”. The influence of movement qi theory on Liu Wansu’s clinical diagnosis and treatment thoughts is mainly reflected in the classification of viscera, meridian and collateral diseases based on the theory of root and branch of middle qi, the diagnosis of pulses based on movement qi theory, the deduction of disease transmission and change using movement qi thinking, and the preparation of medicines based on qi. Liu Wansu initiated the innovation and debate of medical theory in the Jin and Yuan Dynasties, and had a profound impact on the rise of warm febrile diseases in the Ming and Qing Dynasties.