Abstract: There are many researchers on the clinical thinking of Treatise on Cold Damage, and a relatively complete research system on Treatise on Cold Damage has gradually been formed. However, there are still shortcomings, such as incomplete understanding of the clinical value of this book, the diagnosis and treatment of epidemic diseases focusing on febrile diseases and underestimating typhoid fever, problems in how classical theories deal with contemporary diseases and the application of classical prescriptions. This article proposes that Treatise on Cold Damage is the law for all diseases, treating typhoid fever as well as miscellaneous diseases; the diagnosis and treatment of epidemic diseases emphasizes the treatment of febrile disease and underestimates typhoid fever, but in fact, cold and warmth are closely related; classical research can learn from the thinking of western medicine, and the treatment of diseases must be based on Chinese medicine. At present, the application of classic prescriptions focuses on prescriptions and neglects theory and methods, and there is an urgent need to build a standardized system to provide ideas for clinical research on Chinese medicine classics.