Abstract: Malignant tumors are major diseases that seriously threaten human health. Although the integration of traditional Chinese and Western medicine has become an expert consensus on treatment of malignant tumors in China, a mature treatment mode of integrated traditional Chinese and Western medicine has not yet been formed. This paper explores the construction of integrated traditional Chinese and Western medicine treatment mode for malignant tumors, namely synergistic therapy, palliative therapy, and preventive therapy, covering different stages of malignant tumors, in order to give full play to the advantages and characteristics of integrated traditional Chinese and Western medicine treatment in the treatment of malignant tumors.