Abstract: Based on the theory of harmony between man and nature, this article systematically elaborates on the theoretical connotation of "adapt to the time" and emphasizes the significant role of daily rhythm, monthly rhythm, annual rhythm and super annual rhythm in female infertility. This paper proposes that female fertility and the implementation of assisted reproductive technology are influenced by time rhythms. It is recognized that irregular menstruation is the key to the onset of female infertility, and the treatment should focus on regulating menstrual cycle. This article further refines the diagnosis and treatment plan of traditional Chinese medicine for female infertility through methods such as hourly, weekly, seasonal and age adjustment, which provides ideas and methods for clinical diagnosis and treatment of female infertility and the enlightenment of its medication therapy.