OBJECTIVE  To explore the distribution pattern of traditional Chinese medicine (TCM) syndrome types of primary ovarian insufficiency (POI) sleep disorders and the differences in the distribution of sleep quality index among different syndrome types, in order to provide a basis for syndrome differentiation treatment and prevention of POI associated with sleep disorders.

  METHODS  600 POI patients who met the inclusion criteria were collected for epidemiological investigation, and 405 patients who met the diagnosis of sleep disorders were selected as the research group. The patients' general information, TCM four diagnosis and sex hormone level information were collected, and the Pittsburgh sleep quality index (PSQI) scale was used to evaluate patients' sleep conditions, and analyze the characteristics and influencing factors of TCM syndrome types of POI associated with sleep disorders.

  RESULTS  The main TCM syndrome types of POI accompanied by sleep disorders were heart and kidney disharmony syndrome (41.98%), spleen and kidney yang deficiency syndrome (22.22%), kidney deficiency and liver stagnation syndrome (20.99%), and kidney deficiency and blood stasis syndrome (14. 81%). The heart and kidney disharmony syndrome had the longest sleep latency and shortest sleep time, relied more on hypnotic drugs, and had the highest PSQI total score; the heart and kidney disharmony syndrome and kidney deficiency and liver stagnation syndrome had the worst sleep quality; the spleen kidney yang deficiency syndrome had the highest daytime dysfunction score. There was no significant difference in FSH levels among different TCM syndrome types; the distribution of E₂ values from low to high was: heart and kidney disharmony syndrome, kidney deficiency and liver stagnation syndrome, spleen and kidney yang deficiency syndrome, and kidney deficiency and blood stasis syndrome, and there were significant differences among multiple groups (P < 0.05).

  CONCLUSION  The main TCM syndrome types of patients with POI and sleep disorders are heart and kidney disharmony syndrome, spleen and kidney yang deficiency syndrome, kidney deficiency and liver stagnation syndrome, and kidney deficiency and blood stasis syndrome. Among them, the most common TCM syndrome type with the worst sleep quality is heart and kidney disharmony syndrome, which may be closely related to estrogen E₂ levels.