OBJECTIVE  To evaluate the clinical effect of Bushen Yuyin Tiaochong Decoction in the treatment of diminished ovarian reserve (DOR) infertility with kidney-yin deficiency.

  METHODS  60 DOR infertility patients with kidney-yin deficiency from the gynecology outpatient department of the Second Affiliated Hospital of Jiangxi University of Chinese Medicine from October 2020 to April 2023 were selected and divided into the placebo group and the kidney-tonifying group using the random number table method, with 30 cases in each group. Patients in both groups were given oral treatment with dehydroepiandrosterone (DHEA). The placebo group was additionally given placebo. The Bushen Yuyin group was additionally given Bushen Yuyin Tiaochong Decoction. The treatment course for both groups was 3 months. Changes in TCM syndrome scores and reproductive life quality scores were observed before and after treatment. Changes in serum follicle-stimulating hormone (FSH), anti-Mullerian hormone (AMH) and estradiol (E₂) levels in patients were detected by ELISA. The occurrence of adverse reactions during treatment was observed, and the pregnancy rates of the two groups of patients after treatment were recorded.

  RESULTS  After treatment, the total TCM syndrome scores of patients in the Bushen Yuyin group were significantly reduced (P < 0.01), which was better than that of the placebo group (P < 0.01); the reproductive life quality scores of patients in both groups were significantly increased (P < 0.05, P < 0.01), the Bushen Yuyin group was better than the placebo group (P < 0.05); the number of AFC in the Bushen Yuyin group was significantly increased (P < 0.01), which was better than the control group (P < 0.01); the serum AMH levels of patients in both groups were significantly increased (P < 0.05, P < 0.01), and the Bushen Yuyin group was higher than that of the placebo group (P < 0.01); the serum E₂ level of patients in both groups was significantly decreased (P < 0.05, P < 0.01), the Bushen Yuyin group was lower than the placebo group (P < 0.01); the serum FSH level of patients in Bushen Yuyin group was significantly decreased (P < 0.01), which was better than that of the placebo group (P < 0.01); the total pregnancy rate of the Bushen Yuyin group was better than that of the placebo group (P < 0.05); no significant adverse reactions were observed in both groups during the treatment period.

  CONCLUSION  Bushen Yuyin Tiaochong Decoction can significantly improve the pregnancy rate of DOR infertile patients, enhance ovarian function while reducing TCM syndrome scores, improve the quality of reproductive life, and is highly safe.