Abstract: The "common medicines for various diseases" in the preface of Collective Commentaries on the Classic of Materia Medica has been highly praised by medical practitioners for its unique "disease-medicine" outline and clinical practicality, and has continued to be included and developed in later works on materia medica and prescriptions, laying the foundation for the research and development of "specialized prescriptions for specialized diseases" and "specialized medicines for specialized diseases". Tao Hongjing used "the root of major diseases" in Shen Nong's Classic of the Materia Medica as the basic framework, referred to the prescriptions and medicines in Treatise on Cold Damage and Miscellaneous Diseases, and expanded his own and other medical experience to create the "common medicines for various diseases" system, relating and summarizing the representative diseases and main therapeutic effects of medicines, and creating a "disease-medicine" outline system. The construction of the "common medicines for various diseases" system has opened up the precedent of "specialized prescriptions for specialized diseases" and "specialized medicines for specialized diseases", providing new prescription ideas for clinical differentiation and treatment.