Abstract: This article explores the application of Professor Zhou Zhongying's "focus on the core pathogenesis" concept in the context of epidemic hemorrhagic fever and examines how Academician Tong Xiaolin has inherited and developed Professor Zhou's experiences. Influenced by Professor Zhou Zhongying's academic thoughts and considering the contemporary context, Academician Tong Xiaolin, drawing on years of clinical experience, has proposed a new set of Nineteen Pathogenic Factors. Building upon the foundation of the Nineteen Pathogenic Factors in the The Yellow Emperor's Inner Classic, this new framework enriches and expands the understanding of disease location, etiology and pathogenesis, disease classification, and pays attention to a comprehensive understanding of diseases. It emphasizes that the process of seeking the underlying mechanisms should be approached from three aspects: dynamic, state, and condition, rather than solely focusing on the immediate clinical manifestations. This comprehensive approach to understanding disease development offers a fresh perspective and contributes to the application of traditional Chinese Medicine in the diagnosis and treatment of modern diseases.