Abstract: As a malignant tumor with high incidence and mortality worldwide, lung cancer seriously threatens the life and health of human beings. At present, clinical treatment of lung cancer is mainly based on surgery combined with radiotherapy and chemotherapy and other comprehensive treatments, which can control the progression of lung cancer to a certain extent, but there are still problems such as low survival rate and poor quality of life. Autophagy is a complex intracellular self degradation mechanism. The occurrence of autophagy is closely related to autophagy-related gene proteins and signal pathways. Research shows that reasonable regulation of signal pathway can interfere with autophagy leading to lung cancer cell death and inhibit tumor growth. In recent years, the regulation of autophagy-related signaling pathways in Chinese medicine against lung cancer has become a hot spot in the field of oncology research. Therefore, this paper compares and summarizes the research on the regulation of autophagy-related signaling pathways in Chinese medicine against lung cancer in recent years, in order to provide a reference basis for the development of new drugs and clinical application of Chinese medicine against lung cancer.