Abstract: Because of the high safety of medicinal and edible herbs, they are increasingly used in the prevention and treatment of diseases, especially chronic diseases. Myocardial related diseases caused by various myocardial injuries often have poor prognosis, which is an important problem needed to be solved urgently in clinic. Based on a large number of clinical practice experience of Professor WEI Kai-feng and modern pharmacological research, it is found that treatment of Nourishing Yin with Sour and Sweet Tastes has obvious curative effect on chronic cardiomyopathy. In order to facilitate long-term drug use, we conducted literature and experimental research on the varieties of medication-food homologous Chinese medicinal materials under the guidance of the theory of Nourishing Yin with Sour and Sweet Tastes, and finally focused on the improvement of myocardial injury by Corni Fructus-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle drug pair. This article will discuss the theory of Nourishing Yin with Sour and Sweet Tastes, and the research status of Corni Fructus-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle drug pair in alleviating myocardial injury under the guidance of this theory, in order to promote the application of varieties with the medicinal and edible herbs, and better serve for clinical problem solving.