Abstract: This article explores the dialectical approach based on membrane theory by identifying the cause, nature, location, stage, trend, and pathology of the disease. It emphasizes that when identifying the cause of the disease, comprehensive consideration should be given to the pathogenic factors and the syndromes within the membrane system, and attention should be paid to the dynamic nature of the cause; when identifying the nature of the disease, pay attention to the cold and hot attributes, especially the cold and hot inclusions caused by membrane blockage; when identifying the location of the disease, determine whether there is multi-system membrane damage; when identifying the stage of the disease, it is necessary to distinguish Wei, Qi, Ying, blood stages; when identifying the tendency of the disease, compare and analyze the change of healthy and evil Qi; When identifying the pathology of the disease, it is necessary to determine whether there are changes such as membrane Qi block, abnormal water and liquid metabolism, and coexistence of contradictory pathological states. The article emphasizes the understanding of the physiological and pathological characteristics of the systemic membrane system from the perspective of the holistic view and system theory, which provides references for clinical diagnosis and treatment of diseases, especially infectious diseases, multi-system diseases and syndromes, recurrent diseases and syndromes, and difficult diseases and syndromes with unknown etiology.