Abstract: Medicinal plant resources are an important part of Traditional Chinese Medicine, gene editing technology can realize site-specific targeted mutation of genome and innovation of medicinal plants germplasm without introducing other genes. CRISPR gene editing technology, the widely used gene editing technology in recent years, has been investigated and applied in medicinal plants resources, and a corresponding gene editing system has been constructed in Citrus sinensis, Dendrobium officinale, Opium poppy, Salvia miltiorrhiza, Rehmannia glutinosa, Panax ginseng, Ganoderma lucidum, Flammulina filiformis, Shiraia bambusicola, Cordyceps militaris, etc. Research on active components and content regulation of key genes, phenotypic traits, and quality improvement research of key genes, has been carried out in medicinal plants resources. China, the United States, Japan, Brazil, Australia, and other countries have successively issued corresponding regulatory policies for gene editing germplasm innovation, which promotes its industrialization. This paper proposes to further advance the basic research of gene editing germplasm innovation of medicinal plants resources, strengthen the research on drug equivalence after gene editing of germplasm, launch popular science publicity and establish a scientific supervision system.