中药干预非酒精性脂肪性肝炎的机制研究进展

Research Progress on the Mechanism of Traditional Chinese Medicine in the Intervention of Nonalcoholic Steatohepatitis

  • 摘要: 非酒精性脂肪性肝病(Nonalcoholic fatty liver disease, NAFLD) 属于代谢综合征, 已成为一个普遍关注的公共卫生问题。非酒精性脂肪性肝炎(Nonalcoholic steatohepatitis, NASH)是NAFLD的进展性病变, 是由多种风险因素和多种组织器官平行相互作用的结果。由于NASH的潜在病理生理机制十分复杂, 目前还没有获批的药物来控制疾病的发生发展。中医将NAFLD归为“肝癖”范畴, 并将NASH分为肝郁脾虚、痰湿内阻、湿热蕴结及痰瘀互结4个证型。中医以其独特的理论体系和治疗策略, 可以对不同NASH症型进行有效干预和治疗。随着现代药理学和分子生物学的不断发展, 越来越多的研究表明中药复方和单味中药活性成分通过多种机制改善NASH, 从而推进了中医药的应用。为此该文分别从中药复方和单味中药活性成分这两方面重点论述了中药改善NASH的相关机制, 以期为合理有效治疗NASH提供理论和实验研究依据。

     

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is a metabolic syndrome that has become a public health problem of general concern. Nonalcoholic steatohepatitis (NASH) is a progressive NAFLD lesion resulting from the interaction of multiple risk factors with multiorgan involvement. Due to the complex underlying pathophysiologic mechanisms that contribute to the development and progression of NASH, there are no approved drugs to control the progression of the disease. Based on traditional Chinese medicine(TCM) theory, NAFLD belongs to the category of "Ganpi", and was divided into 4 syndrom types: liver stagnation and spleen deficiency, internal obstruction of phlegm and dampness, obstruction of dampness and heat, and interaction of phlegm and blood stasis. Chinese medicine can effectively intervene and treat different clinical types of NASH with its unique theoretical system and treatment strategy. With the continuous development of modern pharmacology and molecular biology, more and more studies have shown that TCM compound formula and active monomers can improve NASH through various mechanisms, which promotes the application of TCM. This review focuses on the mechanisms related to the improvement of NASH by TCM from the perspectives of compound formula and active monomers, in order to provide a theoretical and experimental research basis for the rational and effective treatment of NASH.

     

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