Abstract: With the development of society, the human diseases spectrum has changed dramatically. Compared with the Zhang Zhong-jing era (the late Eastern Han dynasty), geriatric, metabolic, and chronic diseases have gradually become the main disease types in modern society. Thus, the application of Jingfang to treat modern diseases has become a major issue of Jingfang research. In the context of modern medicine, the new application of Jingfang is facing many difficulties. On the one hand, the traditional system of Chinese medicine diagnosis and treatment, on which Jingfang was based, lacks a full understanding of chronic diseases. On the other hand, Jingfang is good at regulating the macroscopic state of the body, but lacks specificity for the physical and chemical indicators of modern diseases. Besides, the dosage rules of Jingfang in the modern system of Chinese medicine diagnosis and treatment are still unclear. Therefore, in order to better apply Jingfang, it is necessary to restructure the Chinese medicine diagnosis and treatment system for modern diseases by referring to Zhang Zhong-jing's diagnosis and treatment model (disease-period-state). In addition, it is also necessary to introduce modern pharmacological achievements into traditional Chinese medicine theory to realize the synchronous regulation of the state and target of Jingfang, and further deepen the research on the dosage-effect relationship of Jingfang so that it can better serve the clinical diagnosis and treatment for modern diseases.