Abstract: From the clinical perspectives, toxic side effects occur after using toxic Chinese medicine. There are multiple reasons, such as lack of attention towards toxicity of Chinese medicine, ignorance of detoxification and controlling knowledge, excessive and long-term use of toxic Chinese medicine, improper use of medicinal materials and processed products, inconsistency between tradition and its usage and dosage, inadequate medical advice after diagnosis and etc. Therefore, it is suggested that Chinese medical practitioners should pay attention to the toxicity and toxic side effects of traditional Chinese medicine; master the theory and methods of controlling and detoxification. They should also select the correct medicinal materials, processed products, dosage forms and medication methods; understand the contemporary toxicological knowledge, and pay attention to the key problems such as the damage to the body caused by taking multiple drugs, so as to use toxic traditional Chinese medicine safely and reasonably.