Abstract: Through summarizing the experience of professor Zhang Qi, a master of Chinese medicine, in the treatment of hepatorenal syndrome(HRS), it is concluded that HRS is a disease of deficiency at the root and excess at the symptoms, which is closely related to the dysfunction of liver, spleen and kidney. In other words, the weakened body resistance, qi stagnation, blood stasis, damp heat, and pathogenic toxins are the key to the disease mechanism. Thus, we should differentiate the deficient and excess causes of the disease to set the treating priorities right. Besides, we should closely follow the mechanism of the disease to treat it in stages. For example, in the early stage, we should dredge the liver and regulate the qi, and strengthen the spleen and stomach; in the middle stage, we should warm the yang and strengthen the spleen, and promote the qi and water movement; in the late stage, we should treat the liver, spleen, and kidneys together, and combine the elimination and supplementation methods at the same time.