Abstract: Inheriting essence and keeping integrity and innovation are the fundamental principles for the high-quality development of TCM and its industry in the new era. The theoretical system of Luobing of TCM, with the general outline of " diagnosis and treatment principle of Luobing " and the two wings of "Mailuo theory" and "Qiluo theory", inherits the academic thoughts, theoretical views and clinical experience of successive doctors on Luobing and combines with modern science and technology to construct an innovative theory systematically, which has opened up a new way for the prevention and treatment of major clinical diseases. Guided by the Luobing theory and based on modern basic and clinical research, the clinical effective prescriptions have been transformed into a series of innovative traditional Chinese medicine drugs, and major breakthroughs have been made in the prevention and treatment of viral respiratory infectious diseases, microangiopathy and neuro-endocrine-immune system diseases and anti-aging.