Abstract: Influenza is an acute respiratory infectious disease caused by influenza virus, which has caused many world influenza pandemics and seriously harmed human health. The nasal cavity is directly connected with the outside world, and is the main entrance of influenza virus into the host. The nasal mucosa and the corresponding immune system on its surface are the first line of defense against pathogen invasion, and play a role in local immunity and stimulate overall immunity in influenza prevention. This paper mainly discusses the advantages of regulating nasal mucosal immunity by external application of Chinese medicine to prevent influenza from the role of nasal mucosal immunity in influenza prevention and the related research of external traditional Chinese medicine based on mucosal immunity in influenza prevention, in order to provide more ideas for external application of Chinese medicine to prevent influenza.