Abstract: Gecko has a long history in Chinese medicine, and is still widely used in the treatment of various tumor diseases at present. In particular, it has the best therapeutic effect on digestive system tumors, and has the advantages of small side effects and so on. Therefore, Gecko is known as the "anti-tumor star". In recent years, scholars have conducted a lot of research reports on the material basis and pharmacological mechanism of gecko in the treatment of tumors, and some research achievements have been made. However, its components are complex and its mechanism of action is still unclear. Therefore, this paper systematically summarizes the herbal research, active components, clinical application and pharmacological action of gecko therapy for cancer, which provides a certain reference for the in-depth study of gecko therapy for cancer and the development of new drugs.