Abstract: The clearance of excessive β-amyloid (Aβ) in the brain is mainly degraded and cleared by autophagy lysosomal system, protease secreted by astrocytes and phagocytosis of microglia. It can also be transported and discharged through blood-brain barrier or brain lymphatic drainage system. The function of spleen in regulating transportation and transformation Aβ metabolism plays an important role. Many experimental evidence shows that Linggui Zhugan decoction, the representative of Wenpi Huayin method, may affect Aβ structures and functions of metabolic related pathways. This paper discusses the scientific connotation transportation and transformation for clear Aβ based on the mechanism of Aβ metabolic pathway and the analysis of the pharmacological effect of Linggui Zhugan decoction, in order to explore the idea of traditional Chinese medicine treatment of Alzheimer's disease.