Abstract: Crohn' s disease (CD) is a chronic, progressive and disabling disease, which seriously affects the quality of life of patients. In recent years, with the continuous listing of biological agents in China, the treatment of CD has entered the era of biological agents, which has brought about continuous upgrading of treatment goals and changes in treatment strategies. Integrated traditional Chinese and western medicine has provided optimized treatment methods for CD patients, so how to make use of the advantages of integrated traditional Chinese and western medicine in the background of biological agents is a importent clinical issue. This article elaborates the treatment strategy for CD under the background of biological agents. Clinically, according to the different clinical manifestations of CD, it can be treated from different perspectives of "Li", "Yang", "Yong", "Luo" and "Lao", from the prevention and treatment of infection, anti-fibrosis, reduction of complications, and improvement of malnutrition In order to adapt to the change of treatment goals and improve clinical efficacy.