Abstract: Evidence-based medicine is the only way for medical development, and the integration with evidence-based medicine is the urgent requirement for the development of traditional Chinese medicine (TCM). However, due to the unique academic characteristics of TCM, how to combine the TCM theories and practical experience with modern evidence-based research has become a difficult problem for the academic progress of TCM. Therefore, through regarding evidence-based research on the classic formula as a breakthrough, we explored the role and significance of combining TCM with evidence-based medicine in dealing with the relationship between syndrome differentiation and disease differentiation, in clarifying the efficacy, in treating new diseases and rare diseases, in the warning of adverse reactions, in the Chinese and western medicine interactions, in the empirical examination on the compatibility of medicines in prescriptions, as well as in the testing and optimization of traditional pharmaceutical methods. In conclusion, this study looks into the future of the evidence-based research on classic formula.