溃疡性结肠炎脾气虚证患者代谢特征研究

Metabolic Characteristics of Spleen-Qi Deficiency Syndrome in Ulcerative Colitis

    摘要
  • 摘要: 目的  基于非靶标代谢组学探索溃疡性结肠炎(UC)脾气虚证的生物学基础。方法  采用液相色谱质谱联用方法对UC脾气虚证和湿热证患者血清进行代谢组学分析。结果  UC脾气虚证存在脂质代谢紊乱, 与UC湿热证患者比较, UC脾气虚证血清中1-油酰基甘油磷酸胆碱、溶血磷脂、鞘氨醇、N-棕榈酰磷酸乙醇胺、棕榈酰肉碱、O-花生四烯酰缩水甘油等代谢产物丰度降低, 2-亚油酰甘油丰度升高。ROC曲线结果显示, O-花生四烯酰缩水甘油、棕榈酰胺、2-亚油酰甘油可能是诊断UC脾气虚证的潜在生物标志物。结论  代谢组学方法有望揭示UC中医证候的生物学本质, 为UC中医辨证提供一定客观依据。

     

    Abstract: OBJECTIVE  To explore the biological basis of spleen-qi deficiency syndrome of ulcerative colitis based on non-target metabolomics.METHODS  The UC patients with spleen-qi deficiency syndrome and damp-heat syndrome were analyzed by metabolomics by LC-MS.RESULTS  There were lipid metabolism disorders in UC patients with spleen-qi deficiency. Compared with UC patients with damp-heat, the average abundance of 1-linoleoylglycerophosphocholine, lysophospholipid, sphingosine, N-palmitoyl-phosphoethanolamine, palmitoylcarnitine and O-arachidonoyl glycidol decreased in the UC patients with spleen-qi deficiency, while the average abundance of 2-linoleoyl glycerol increased. ROC curve showed that O-arachidonoyl glycidol, palmitic amide and 2-linoleoyl glycerol may be potential biomarkers of spleen-qi deficiency syndrome in UC.CONCLUSION  Metabolomics is expected to reveal the biological nature of TCM syndromes in UC.

     

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