Abstract: Professor Zhou Zhongying, a master of traditional Chinese medicine, advocated a new system of syndrome differentiation and treatment based on pathomechanism in Chinese medicine. He proposed that the basic characteristics of the pathomechanism of the complicated disease were their complexities, and pointed out that compound prescriptions was the basic strategy for the treatment of those diseases such as tumors. Closely revolving around the subject of syndrome differentiation based on pathomechanism, the study summarizes Zhou Zhongying's experience in the prescribing and applying formulae for malignant tumors from three aspects including the theoretical basis of compound prescriptions, the basic ideas of compound prescriptions, as well as the similarities and differences of compound prescriptions for different tumors, to further expand the ideas of prescribing and applying formulae along with clinical diagnosing and treating of complicated diseases such as tumors.