Abstract: OBJECTIVE  To evaluate the effect of Suxiao Jiuxin pills on myocardial damage in acute ST-segment elevation myocardial infarction (STEMI) with qi stagnation and blood stasis based on intracoronary electrocardiogram.METHODS  60 acute STEMI patients with qi stagnation and blood stasis who underwent percutaneous coronary intervention (PCI) directly from March 2019 to February 2020 at Integrated Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine were selected. Besides, according to the random number table, these patients were divided into the control group and the study group, with 30 cases in each group. The two groups were given standard preoperative treatment, while based on that, the study group was given sublingual administration of Suxiao Jiuxin pills. The clinical efficacy of traditional Chinese medicine (TCM), as well as TCM syndrome score and adverse reactions were compared between the two groups after one week of treatment. In addition, the value of ST-segment resolution (ΔIST) of intracoronary electrocardiogram combined with the blood flow of thrombolysis and thrombin inhibition in myocardial infarction (TIMI) were compared after PCI.RESULTS  The TCM clinical efficacy and ΔIST in the study group were significantly higher than those in the control group (P < 0.05), while the TCM syndrome scores of both groups were decreased significantly (P < 0.01). In addition, the syndrome scores of chest distress, distention and fullness in the chest and hypochondriac region, as well as spontaneous sweating in the study group were significantly lower than those in the control group (P < 0.05). However, there was no statistical difference in the postoperative TIMI flow grades and adverse reactions between the two groups (P>0.05).CONCLUSION  Preoperative administration of Suxiao Jiuxin pills can further reduce myocardial damage, alleviate clinical symptoms, and enhance the TCM clinical efficacy without increasing adverse reactions in patients with acute STEMI with qi stagnation and blood stasis.