Abstract: Lasiosphaera seu Calvatia belongs to fungal traditional Chinese medicine, which has the effects of detumescence, hemostasis and detoxification, and is often used to treat traumatic bleeding in the form of powder. Ancient books and modern clinical records have found that Lasiosphaera seu Calvatia has the effect of treating chronic refractory wounds. Aiming to investigate the active material basis, pharmacological action and mechanism of Lasiosphaera seu Calvatia in the treatment of chronic refractory wounds in the present articals, the authors reviewed the recent reports on peeling Lasiosphaera fenzlii Reich., Calvatia gigantea (Batsch ex Pers.) Lloyd and Calvatia lilacina (Mont.et Berk.) Lloyd at home and abroad, and sorted out more than 100 types of chemical constituents, including steroids, proteins and peptides, amino acids, fatty acids and esters, sugars and volatile components, etc.The main pharmacological effects are reported for hemostasis, anti-inflammation, antioxidation, bacteriostasis, hypoglycemia, promoting cell proliferation and etc. By regulating wound microenvironment, promoting the process of cell proliferation, restoring chronic refractory wound healing, Lasiosphaera seu Calvatia is expected to be used as medicinal materials and utilized in wound repair treatment, in order to provide a theoretical basis for the rational development and utilization of Lasiosphaera seu Calvatia resources in the field of clinical trauma treatment.