Abstract: In terms of the concept, yin-yang property, pathogenesis and transformation rules of cancerous toxin, the paper summarizes the research status of cancerous toxin, draws that there is no unified understanding of the concept, etiology, and pathogenesis, and the yin-yang property, transformation rules of cancerous toxin deserved further study. Moreover, it proposes the prospects of cancerous toxin, including unifying the concept of cancerous toxin in the academic circles, constructing the syndrome differentiation of cancerous toxin theory in different cancers, improving the study of the transformation rules of cancerous toxin, promoting the integration of Chinese medicine and Western medicine in the treatment of malignant tumor, thus realizing the construction of clinical-oriented cancerous toxin theory.