Abstract: The modernization of traditional Chinese medicine (TCM) has made some achievements in the past two decades, but there are still many obstacles. With the application of artificial intelligence(AI)technology in the field of Biological Science (including protein structure analysis, new drug development, etc.), it may bring new research ideas and strategies for the breakthrough of obstacles restricting the modernization of TCM. The continuous accumulation of clinical and research data of TCM also provides the basis for the integration of AI and TCM. This article analyzes the hotspot and forward of AI in the field of TCM, then further investigates the enormous impetus of AI technology in the research of key scientific issues of TCM, such as the inheritance and innovation of academic ideas of TCM masters, the modern biological basis of TCM therapeutic principle, the material basis and mechanism of action of TCM. Those may be the strategic resource and competition point for the modernization of TCM in the future.