Abstract: The α-glucosidase inhibitors (AGIs) are a kind of new antidiabetic drugs that can slow down the absorption of glucose in the intestinal tract and reduce postprandial blood glucose. AGIs can stabilize and gradually maintain blood glucose at a certain level without inducing complications. However, the number of AGIs drugs on the market is small and all of them have certain side effects, which makes it of great significance to develop new AGIs. As an important source of drug development, the marine natural product is an important way to find new AGIs. In this paper, natural AGIs from 59 marine animals, algae and microorganisms were reviewed to provide references for the development of new safe and efficient AGIs from marine natural products.