Abstract: Febrile seizure is a common clinical emergency and intensive disease in pediatrics, the prevention and treatment of pediatric febrile seizure should follow the principles of combining disease and syndrome, preventing seizure with the development of disease, and preventing diseases before onset. During the acute exacerbation period, the basic treatment is to clear heat, eliminate phlegm, relieve seizure, and stop wind based on performing antispasmodic measures for the first, and identifying four syndromes including heat, phlegm, fright, and wind. At the initial stage of the disease, antipyretic and antispasmodic medicine such as Lingzhu powder should be applied as early as possible to prevent seizure caused by extreme heat. During the interictal period, the main treatment is to adjust the physical condition. Jinping decoction is prescribed to supplement the lung and consolidate the exterior along with nourish the heart and calm the liver, to achieve the purpose of preventing before disease onset, preventing fever from external contraction, and reducing the occurrence of seizure.